枇杷花黄酮提取液缓解小鼠肠道运动障碍的作用
姜 帆1,高慧颖2,郭小玲3,陈 亮4*,郑少泉1*

(1.福建省农业科学院果树研究所,福建省龙眼枇杷育种工程技术研究中心,福建 福州 350013; 2.福建省农业科学院农业工程技术研究所,福建 福州 350003; 3.厦门大学环境与生态学院,福建 厦门 361102; 4.厦门大学生命科学学院,厦门市植物遗传重点实验室,福建 厦门 361102)

枇杷花; 黄酮提取液; 肠道运动障碍; 小鼠结肠突触素

Effect of Eriobotrya japonica flower flavonides extract on intestinal motility disorders in mice
JIANG Fan1,GAO Huiying2,GUO Xiaoling3,CHEN Liang4*,ZHENG Shaoquan1*

(1.Fujian Fruit Breeding Engineering Technology Research Center for Longan & Loquat,Fruit Research Institute,Fujian Academy of Agricultural Science,Fuzhou 350013,China; 2.Institute of Agricultural Engineering Technology,Fujian Academy of Agricultural

Eriobotrya japonica flower; flavonides extract; intestinal motility disorders; colonic synaptophysin

DOI: 10.6043/j.issn.0438-0479.201805002

备注

以枇杷(Eriobotrya japonica Lindl.)花黄酮提取液(EjFF)为受试物,采用复方地芬诺酯建立小鼠便秘模型,通过小鼠小肠推进实验和排便实验,评估其对小鼠的首粒排便时间、5 h内排便粒数和排便量、小肠墨汁推进率以及小鼠结肠突触素(SY)含量的影响.结果显示:EjFF不影响小鼠体质量,但能显著缩短小鼠排便时间,增加5 h内排便粒数和排便量,提高小肠墨汁推进率,并提高小鼠结肠SY含量(p<0.05).上述结果表明EjFF可以有效缓解小肠运动障碍.

Eriobotrya japonica flower flavonides extract(EjFF)was studied regarding its ability to mitigate intestinal motility disorders.A mouse model of diphenoxylate-induced constipation was established in the bowel evacuation and intestinal motility experiments.The first evacuation time,the number of fecal pellets and the weight of faces in 5 h,the movement rate of ink in the small intestine,and the effect on colonic synaptophysin(SY)contents were measured.The results showed that EjFF intragastical administration had no effect on body weights of mice,while compared with the model group,the groups treated with EjFF exhibited a shortened evacuation time,an increased number of fecal pellets,an increased weight of feces in 5 h,an increased movement rate of ink,and increased SY contents(p<0.05).Therefore,the results demonstrate that EjFF can mitigate intestinal motility disorders in mice.