miRNAs调控动脉粥样硬化相关细胞功能研究进展
陈笑梅,牟雅琳,吕 鹏,刘 刚*

(厦门大学 公共卫生学院,分子影像暨转化医学研究中心,福建 厦门 361102)

miRNA; 动脉粥样硬化; 内皮细胞; 血管平滑肌细胞; 巨噬细胞

Research Progresses of miRNAs in Regulation of Cellular Functions in Atherosclerosis
CHEN Xiaomei,MU Yalin,LU ·· Peng,LIU Gang*

(Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China)

miRNA; atherosclerosis; endothelial cell; vascular smooth muscle cell; macrophage

DOI: 10.6043/j.issn.0438-0479.201805014

备注

动脉粥样硬化及其所引起的恶性心血管疾病,如心肌梗死、中风,是当前致死和致伤残的主要原因.miRNAs是生物进化过程中的一组高度保守的非编码单链RNA小分子,是动脉粥样硬化病理生理细胞效应的主要调节者.主要综述了miRNAs在动脉粥样硬化发展进程中,对内皮细胞、血管平滑肌细胞和巨噬细胞功能的调节作用.

Atherosclerosis and its accompanying clinical disease,such as stroke,myocardial infarction,are the leading cause of mortality and morbidity in the world.Over the past decade,miRNAs have emerged as evolutionarily conservednon-coding single-strand RNA moleculesand serve as important regulators of pathophysiological cellular effects involved in atherosclerosis.This review aims to provide a comprehensive perspective of miRNAs,mostly focusing on mechanism and relevance in regulating endothelial cell,vascular smooth muscle cell and macrophage functions in the pathogenesis of atherosclerosis.