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[1]陈本强,苏雅璇,周志东*.电激励下基于挠曲电效应的外毛细胞力电耦合分析[J].厦门大学学报(自然科学版),2019,58(04):567-573.[doi:10.6043/j.issn.0438-0479.201810013]
 CHEN Benqiang,SU Yaxuan,ZHOU Zhidong*.Electromechanical coupling analysis of outer hair cells based on flexoelectric effect under the electrical stimulation[J].Journal of Xiamen University(Natural Science),2019,58(04):567-573.[doi:10.6043/j.issn.0438-0479.201810013]
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电激励下基于挠曲电效应的外毛细胞力电耦合分析(PDF/HTML)
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《厦门大学学报(自然科学版)》[ISSN:0438-0479/CN:35-1070/N]

卷:
58卷
期数:
2019年04期
页码:
567-573
栏目:
研究论文
出版日期:
2019-07-28

文章信息/Info

Title:
Electromechanical coupling analysis of outer hair cells based on flexoelectric effect under the electrical stimulation
文章编号:
0438-0479(2019)04-0567-07
作者:
陈本强1苏雅璇2周志东1*
1.厦门大学材料学院,福建省特种先进材料重点实验室,福建 厦门 361005; 2.集美大学诚毅学院,福建 厦门 361021
Author(s):
CHEN Benqiang1SU Yaxuan2ZHOU Zhidong1*
1.Fujian Key Laboratory of Advanced Materials,College of Materials,Xiamen University,Xiamen 361005,China; 2.Chengyi University College,Jimei University,Xiamen 361021,China
关键词:
挠曲电效应 电动性 等效压电系数 外毛细胞
Keywords:
flexoelectric effect electromotility equivalent piezoelectric coefficient outer hair cells
分类号:
O 321
DOI:
10.6043/j.issn.0438-0479.201810013
文献标志码:
A
摘要:
耳蜗内的外毛细胞在电激励下的力电耦合运动是耳蜗放大主动机制的重要基础.以耳蜗外毛细胞为研究对象,基于外毛细胞侧壁的特殊膜结构,推导膜曲率变化、轴向伸缩与跨膜电位差之间的相互关系,建立外毛细胞挠曲电-压电线性等效模型,进而获得整体的等效压电系数.建立外加电激励下细胞轴向振动的动力学控制方程和动态电学方程,并结合相应的力学和电学边界条件进行分析,从频域上讨论细胞材料参数和流体阻力对外毛细胞电动性机制的影响.计算结果表明:在高频区域随着激励频率的增加,流体阻力限制机械功的输出; 机械功输出大小和峰值所对应的激励频率与细胞长度、外膜挠曲电系数和细胞基部电阻抗有关,当细胞越长、挠曲电系数或细胞基部电阻抗越大时,机械功输出越大,其对应峰值的激励频率越小.
Abstract:
The electromechanical coupling response of cochlear outer hair cells under the electrical stimulation contitutes an important basis for the active mechanism of cochlear enlargement.Based on the special membrane structure of outer hair cell sidewall,the relationship among membrane curvature,axial stretching and transmembrane potential difference is deduced.The effective flexoelectric-piezoelectric linear model of outer hair cells is established,and the effective piezoelectric coefficient has been obtained.The dynamic governing equation and dynamic electrical equation of the axial vibration under the external electrical stimulation are derived.With corresponding mechanical and electrical boundary conditions,the influence of material parameters and fluid resistance on electromotility mechanisms of outer hair cells are analyzed and discussed in the frequency domain.Calculation results show that the fluid resistance will restrict the mechanical power output with increasing stimulus frequencies in the high frequency zone.The mechanical power output and peak frequency are related to the cell length,flexoelectric coefficient of outer membrane and electrical impedance at the end of cells.The long cells,the large flexoelectric coefficients and electrical impedances will lead to the large mechanical power output and smaller peak frequencie.

参考文献/References:

[1] ASHMORE J. Cochlear outer hair cell motility[J]. Physiological Reviews,2008,88(1):173-210.
[2] BROWNELL W E,SPECTOR A A,RAPHAEL R M,et al.Micro-and nanomechanics of the cochlear outer hair cell[J].Annual Review of Biomedical Engineering,2001,3(3):169-194.
[3] FETTIPLACE R,HACKNEY C M.The sensory and motor roles of auditory hair cells[J].Nature Reviews Neuroscience,2006,7(1):19-29.
[4] DAVIS H.An active process in cochlear mechanics[J].Hear Res,1983,9(1):79-90.
[5] ASHMORE J F.A fast motile response in guinea-pig outer hair cells:the cellular basis of the cochlear amplifier[J].The Journal of Physiology,1987,388(1):323-347.
[6] BROWNELL W E,BADER C R,BERTRAND D,et al.Evoked mechanical responses of isolated cochlear outer hair cells[J].Science,1985,227(4683):194-196.
[7] HOLLEY M C.Outer hair cell motility[M]∥The cochlea.New York:Springer,1996:386-434.
[8] LINERMAN M C,GAO J,HE D Z,et al.Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier[J].Nature,2002,419(6904):300-304.
[9] DALLOS P,HALLWORTH R,EVANS B N.Theory of electrically driven shape changes of cochlear outer hair cells[J].Journal of Neurophysiology,1993,70(1):299-323.
[10] MOUNTAIN D C,HUBBARD A E.A piezoelectric model of outer hair cell function[J].Journal of the Acoustical Society of America,1994,95(1):350-354.
[11] IWASA K H.A two-state piezoelectric model for outer hair cell motility[J].Biophysical Journal,2001,81(5):2495-2506.
[12] FURNESS D N,HACKNEY C M.Comparative ultras-tructure of subsurface cisternae in inner and outer hair cells of the guinea pig cochlea[J].Eur Arch Otorhino-laryngol,1990,247(1):12-15.
[13] DIELER R,SHEHATA-DIELER W E,BROWNELL W E.Concomitant salicylate-induced alterations of outer hair cell subsurface cisternae and electromotility[J].Journal of Neurocytology,1991,20(8):637-653.
[14] HOLLEY M C,KALINEC F,KACHAR B.Structure of the cortical cytoskeleton in mammalian outer hair cells[J].Journal of Cell Science,1992,102(3):569-580.
[15] RAPHAEL R M,POPEL A S,BROWNELL W E.A membrane bending model of outer hair cell electromotility[J].Biophysical Journal,2000,78(6):2844-2862.
[16] WEITZEL E K,TASKER R,BROWNEL W E.Outer hair cell piezoelectricity:frequency response enhancementand resonance behavior[J].Journal of the Acoustical Society of America,2003,114(3):1462-1466.
[17] RABBITT R D,CLIFFORD S,BRENEMAN K D,et al.Power efficiency of outer hair cell somatic electromotility[J].Plos Computational Biology,2009,5(7):e1000444.
[18] BRENEMAN K D,BROWNELL W E,RABBITT R D.Hair cell bundles:flexoelectric motors of the inner ear[J].Plos One,2009,4(4):e5201.
[19] SPENCER A J M.Continuum mechanics[M].Lodon:longman,1980:183-200.
[20] 徐昕,李国华.神经元的电缆性质Ⅰ电缆方程及其稳态解[J].沈阳师范大学学报(自然科学版),1999(1):56-61.
[21] 杜修力.工程波动理论与方法[M].北京:科学出版社,2009:7-23.
[22] FRANK G,HEMMERT W,GUMMER A W.Limiting dynamics of high-frequency electromechanical transduction of outer hair cells[J].Proceedings of the National Academy of Sciences of the United States of America,1999,96(8):4420-4425.
[23] 李轶,贾淑萍,龚树生,等.离子通道和机械负荷对耳蜗外毛细胞电致运动的影响[J].首都医科大学学报,2014,35(4):477-482.
[24] LIAO Z,POPEL A S,BROWNELL W E,et al.High-frequency force generation in the constrained cochlear outer hair cell:amodel study[J].Journal of the Associa-tion for Research in Otolaryngology,2005,6(4):378-389.
[25] LIAO Z,POPEL A S,BROWNELL W E,et al.Modeling high-frequency electromotility of cochlear outer hair cell in microchamber experiment[J].The Journal of the Acoustical Society of America,2005,117(4):2147-2157.

备注/Memo

备注/Memo:
收稿日期:2018-10-15 录用日期:2019-01-12
基金项目:国家自然科学基金(11572271)
*通信作者:zdzhou@xmu.edu.cn
更新日期/Last Update: 1900-01-01