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[1]陈笑梅,牟雅琳,吕 鹏,等.miRNAs调控动脉粥样硬化相关细胞功能研究进展[J].厦门大学学报(自然科学版),2018,57(05):593-601.[doi:10.6043/j.issn.0438-0479.201805014]
 CHEN Xiaomei,MU Yalin,LU ·· Peng,et al.Research Progresses of miRNAs in Regulation of Cellular Functions in Atherosclerosis[J].Journal of Xiamen University(Natural Science),2018,57(05):593-601.[doi:10.6043/j.issn.0438-0479.201805014]
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miRNAs调控动脉粥样硬化相关细胞功能研究进展(PDF/HTML)
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《厦门大学学报(自然科学版)》[ISSN:0438-0479/CN:35-1070/N]

卷:
57卷
期数:
2018年05期
页码:
593-601
栏目:
综述
出版日期:
2018-09-27

文章信息/Info

Title:
Research Progresses of miRNAs in Regulation of Cellular Functions in Atherosclerosis
文章编号:
0438-0479(2018)05-0593-09
作者:
陈笑梅牟雅琳吕 鹏刘 刚*
厦门大学 公共卫生学院,分子影像暨转化医学研究中心,福建 厦门 361102
Author(s):
CHEN XiaomeiMU YalinLU ·· PengLIU Gang*
Center for Molecular Imaging and Translational Medicine,School of Public Health,Xiamen University,Xiamen 361102,China
关键词:
miRNA 动脉粥样硬化 内皮细胞 血管平滑肌细胞 巨噬细胞
Keywords:
miRNA atherosclerosis endothelial cell vascular smooth muscle cell macrophage
分类号:
R 543
DOI:
10.6043/j.issn.0438-0479.201805014
文献标志码:
A
摘要:
动脉粥样硬化及其所引起的恶性心血管疾病,如心肌梗死、中风,是当前致死和致伤残的主要原因.miRNAs是生物进化过程中的一组高度保守的非编码单链RNA小分子,是动脉粥样硬化病理生理细胞效应的主要调节者.主要综述了miRNAs在动脉粥样硬化发展进程中,对内皮细胞、血管平滑肌细胞和巨噬细胞功能的调节作用.
Abstract:
Atherosclerosis and its accompanying clinical disease,such as stroke,myocardial infarction,are the leading cause of mortality and morbidity in the world.Over the past decade,miRNAs have emerged as evolutionarily conservednon-coding single-strand RNA moleculesand serve as important regulators of pathophysiological cellular effects involved in atherosclerosis.This review aims to provide a comprehensive perspective of miRNAs,mostly focusing on mechanism and relevance in regulating endothelial cell,vascular smooth muscle cell and macrophage functions in the pathogenesis of atherosclerosis.

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备注/Memo

备注/Memo:
收稿日期:2018-05-11 录用日期:2018-07-11
基金项目:国家重点研发计划(2017YFA0205201,2014CB744503, 2013CB733802); 国家自然科学基金(81422023, 51273165, U1705281, U1505221); 教育部新世纪优秀人才支持计划(ncet-13-0502)
*通信作者:gangliu.cmitm@xmu.edu.cn
引文格式:陈笑梅,牟雅琳,吕鹏,等.miRNAs调控动脉粥样硬化相关细胞功能研究进展[J].厦门大学学报(自然科学版),2018,57(5):593-601.
Citation:CHEN X M,MU Y L,LU ·· P,et al.Research progresses of miRNAs in regulation of cellular functions in atherosclerosis[J].J Xiamen Univ Nat Sci,2018,57(5):593-601.(in Chinese)
更新日期/Last Update: 1900-01-01