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《厦门大学学报（自然科学版）》[ISSN:0438-0479/CN:35-1070/N]

卷:

56卷

期数:

2017年01期

页码:

137-141

栏目:

研究简报

出版日期:

2017-01-23

文章信息/Info

Title:

Evaluation of the Role of IgE Responses to Der f 1 and Der f 2 in House Dust Mite-allergic Patients

文章编号:

0438-0479(2017)01-0137-05

作者:

董劲春; 程 浩^*

浙江大学医学院附属邵逸夫医院,浙江 杭州 310016

Author(s):

DONG Jinchun; CHENG Hao^*

Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China

关键词:

粉尘螨;  过敏原;  Der f 1;  Der f 2

Keywords:

Dermatophagoides farinae;  allergen;  Der f 1;  Der f 2

分类号:

R 392.8

DOI:

10.6043/j.issn.0438-0479.201603030

文献标志码:

A

摘要:

为了解粉尘螨(Dermatophagoides farinae)过敏患者对粉尘螨单组分过敏原Der f 1和Der f 2特异性IgE的水平情况,收集了80例疑似尘螨过敏患者样本,对ImmunoCAP过敏原检测系统和浙江大学迪迅粉尘螨检测试剂盒检测的粉尘螨特异性IgE阳性样本,进一步检测其粉尘螨单组分过敏原Der f 1和Der f 2特异性IgE水平.80例样本中2种方法检测粉尘螨均为阳性的有65例,阳性率为81.3%.65例阳性样本中,Der f 1阳性率为87.7%,Der f 2阳性率为90.8%,二者至少一个为阳性的达96.99%,Der f 2特异性IgE水平显著高于Der f 1.儿童的粉尘螨及其2种单组分过敏原Der f 1和Der f 2特异性IgE水平显著高于成人.综上,Der f 1和Der f 2这2种组分过敏原在我国粉尘螨患者中占据了主导地位,两者特异性IgE水平存在显著差异,后者高于前者,且儿童的敏感性显著高于成人.

Abstract:

To investigate the status of the Der f 1 and Der f 2 specific IgE in house dust mite-allergic patients,eighty patients were enrolled,and their serum IgE reactivity to Dermatophagoides farinae(Df),was measured with ImmunoCAP and Zheda Dixun Immuno-blotting method.Serum IgE reactivity to Der f 1 and Der f 2 was also measured in Df-allergic patients.Results showed that 81.3%(65 cases)had positive Df specific IgE in 80 cases in both measurements.Most Df positive patients were sensitized to Der f 1(87.7% positive)and Der f 2(90.8% positive),with both allergens together(96.9% positive)largely responsible for the total anti-Df IgE response.The specific IgE value of Der f 2 was significantly higher than that of Der f 1.Overall,IgE responses to Df and its two major allergen components were higher in children than in adults in this study.These results suggest that Der f 1 and Der f 2 are the dominant allergens in patients with Df allergy in China.Significant difference in the IgE level exists between Der f 1 and Der f 2,with the latter higher than the former.Children have higher IgE concentration of Der f 1 and Der f 2 than adults.

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备注/Memo

备注/Memo:

收稿日期:2016-03-18 录用日期:2016-03-23
基金项目:浙江省重大(重点)国际科技合作项目(2009C14029)
*通信作者:hz_chenghao@126.com

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