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Three-zone Simulated Moving Bed for Separation of o-Vanillin and Vanillin(PDF)

Journal of Xiamen University(Natural Science)[ISSN:0438-0479/CN:35-1070/N]

2017 04
Research Field:
Research Articles
Publishing date:


Three-zone Simulated Moving Bed for Separation of o-Vanillin and Vanillin
Article ID:
CHEN JinliangYAO Chuanyi*LU Yinghua
College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China
simulated moving bed(SMB) o-vanillin vanillin asynchronous switching optimization
CLC number:
TQ 028
Document code:

In this study,the separation models of o-vanillin and vanillin with three-zone simulated moving bed(SMB)and Varicol were built.The separation of these two compounds was achieved successfully with high efficiency and high purity in the experiment.Firstly,the mobile phase of 35%(by vol.)aqueous alcohol and the stationary phase of reverse phase C18 silica gel were determined.The adsorption isotherms of these two compounds were determined with single-component frontal analysis.The lumped mass transfer coefficients and axial diffusion coefficients of o-vanillin and vanillin were calculated with empirical formula.Then,the SMB and Varicol models were structured based on the linear driving force model.The operation parameters were optimized for maximization of throughput using the complex method with purities of the two compounds constrained to be greater than 99.5% and the flow rate of desorbent fixed at 2.0 mL/min.The result was experimentally validated.Through optimization,the maximum throughput of SMB was 0.481 mL/min.The experimental purities of o-vanillin and vanillin under the optimized conditions were 99.3% and 99.0% respectively.The optimized maximum throughput of Varicol was 0.551 mL/min,which is 14.6% greater than that in SMB,with the experimental purity of 99.2% for o-vanillin and 99.1% for vanillin under the optimized conditions.


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收稿日期:2016-09-14 录用日期:2016-12-03
Last Update: 1900-01-01