|Table of Contents|

Three-zone Simulated Moving Bed for Separation of o-Vanillin and Vanillin(PDF)

Journal of Xiamen University(Natural Science)[ISSN:0438-0479/CN:35-1070/N]

Issue:
2017 04
Page:
492-498
Research Field:
Research Articles
Publishing date:
2017-07-26

Info

Title:
Three-zone Simulated Moving Bed for Separation of o-Vanillin and Vanillin
Article ID:
0438-0479(2017)04-0492-07
Author(s):
CHEN JinliangYAO Chuanyi*LU Yinghua
College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China
Keywords:
simulated moving bed(SMB) o-vanillin vanillin asynchronous switching optimization
CLC number:
TQ 028
DOI:
10.6043/j.issn.0438-0479.201609021
Document code:

A
Abstract:
In this study,the separation models of o-vanillin and vanillin with three-zone simulated moving bed(SMB)and Varicol were built.The separation of these two compounds was achieved successfully with high efficiency and high purity in the experiment.Firstly,the mobile phase of 35%(by vol.)aqueous alcohol and the stationary phase of reverse phase C18 silica gel were determined.The adsorption isotherms of these two compounds were determined with single-component frontal analysis.The lumped mass transfer coefficients and axial diffusion coefficients of o-vanillin and vanillin were calculated with empirical formula.Then,the SMB and Varicol models were structured based on the linear driving force model.The operation parameters were optimized for maximization of throughput using the complex method with purities of the two compounds constrained to be greater than 99.5% and the flow rate of desorbent fixed at 2.0 mL/min.The result was experimentally validated.Through optimization,the maximum throughput of SMB was 0.481 mL/min.The experimental purities of o-vanillin and vanillin under the optimized conditions were 99.3% and 99.0% respectively.The optimized maximum throughput of Varicol was 0.551 mL/min,which is 14.6% greater than that in SMB,with the experimental purity of 99.2% for o-vanillin and 99.1% for vanillin under the optimized conditions.

References:

[1] 杨文文,吴秋林,唐鸿志,等.“香料皇后”:天然香兰素生物合成的研究进展[J].微生物学通报,2013,40(6):1087-1095.
[2] FACHE M,BOUTEVIN B,CAILLOL S.Vanillin production from lignin and its use as a renewable chemical[J].ACS Sustainable Chemistry & Engineering,2016,4(1):35-46.
[3] 贺旻.Reimer-Tiemann反应的研究及其应用[J].大连大学学报,1992,13(4):75-79.
[4] 李中柱,邹瑛.Reimer-Tiemann反应合成香草醛[J].化学世界,1991(1):18-19.
[5] 杨渐飞,杨亚圣,周联波,等.一种邻位香兰素和香兰素混合物的分离纯化方法:CN102718640A [P].2012-10-10.
[6] 季卫刚,文泽平,赵华文,等.甲基或乙基香兰素的精制方法:CN101838188A [P].2010-09-22.
[7] YU Y,WOOD K R,LIU Y A.Simulation and comparison of operational modes in simulated moving bed chromato-graphy[J].Industrial & Engineering Chemistry Research,2015,54(46):11576-11591.
[8] GONCALVES J C,RODRIGUES A E.Simulated moving bed reactor for p-xylene production:adsorbent and catalyst homogeneous mixture[J].Chemical Engineering Journal,2014,258:194-202.
[9] GONCALVES J C,RODRIGUES A E.Simulated moving bed reactor for p-xylene production:dual-bed column[J].Chemical Engineering and Processing:Process Intensification,2016,104:75-83.
[10] 雷光鸿,姜毅,魏承厚,等.模拟移动床色谱分离蔗髓提取物制备L-阿拉伯糖和D-木糖的研究与应用[J].食品科技,2015(3):214-217.
[11] LI M,BAO Z,XING H,et al.Simulated moving bed chromatography for the separation of ethyl esters of eicosapentaenoic acid and docosahexaenoic acid under nonlinear conditions[J].Journal of Chromatography A,2015,1425:189-197.
[12] ZHANG Z,MAZZOTTI M,MORBIDELLI M.Multiobjective optimization of simulated moving bed and Varicol processes using a genetic algorithm[J].Journal of Chromatography A,2003,989(1):95-108.
[13] 陈韬,陈贤铬,徐俊烨,等.模拟移动床色谱法拆分甲霜灵对映体[J].色谱,2016,34(1):68-73.
[14] GONG R,LIN X,LI P,et al.Experiment and modeling for the separation of guaifenesin enantiomers using si-mulated moving bed and Varicol units[J].Journal of Chromatography A,2014,1363:242-249.
[15] YAO C,TANG S,YAO H M,et al.Study on the number of decision variables in design and optimization of Varicol process[J].Computers & Chemical Enginee-ring,2014,68:114-122.
[16] MUN S.Strategy of rearranging the port locations in a three-zone simulated moving bed chromatography for binary separation with linear isotherms[J].Journal of Chromatography A,2012,1230(18):100-109.
[17] GUIOCHON G,SHIRAZI S G,KATTI A M.Fundamentals of preparative and nonlinear chromatography[M].New York:Academic Press,1994:236-281.
[18] LIN B,GOLSHANSHIRAZI S,GUIOCHON G.Effect of mass transfer coefficient on the elution profile in nonlinear chromatography[J].Journal of Physical Chemistry,1989,93(8):3363-3368.
[19] CHUNG S F,WEN C Y.Longitudinal dispersion of liquid flowing through fixed and fluidized beds[J].AIChE Journal,1968,14(6):857-866.
[20] POLING B E,PRAUSNITZ J M,O’CONNELL J P.The properties of gases and liquids[M].New York:McGraw-Hill,2001:143-145.
[21] WILLIAMSON J E,BAZAIRE K E,GEANKOPLIS C J.Liquid-phase mass transfer at low reynolds numbers[J].Industrial & Engineering Chemistry Fundamentals,1963,2(2):126-129.
[22] STORTI G,MAZZOTTI M,MORBIDELLI M,et al.Robust design of binary countercurrent adsorption separation processes[J].AIChE Journal,1993,39(3):471-492.
[23] MAZZOTTI M,STORTI G,MORBIDELLI M.Robust design of countercurrent adsorption separation processes:2.multicomponent systems[J].AIChE Journal,1994,40(11):1825-1842.
[24] YAO C,TANG S,LU Y,et al.Combination of space-time conservation element/solution element method and continuous prediction technique for accelerated simulation of simulated moving bed chromatography[J].Chemical Engineering & Processing,2015,96:54-61.

Memo

Memo:
收稿日期:2016-09-14 录用日期:2016-12-03
基金项目:厦门市科技计划项目(3502Z20143008)
*通信作者:cyao@xmu.edu.cn
Last Update: 1900-01-01